NanoBase™ · Serum Architecture
NanoBase™ Classic.
The serum-class member of the NanoBase™ family. A fluid, fully modular tri-domain nano-colloidal architecture engineered at ~185 nm and held by engineered interfacial charge rather than by surfactant HLB balancing. You build your finished serum on top of it with room-temperature mixing — no nano equipment, no added water, no added surfactant.
Serum architecture
~85% typical use
Any CM can build on it
Clean preservation
At a glance
~185 nmEngineered mean particle size, DLS-confirmed
pH 5.7–6.0Working window; 5.9 nominal
3 domainsNanoemulsion · nanoliposomal · nanomicellar
~85%Typical use level in the finished serum
How it holds
Charge, not surfactant balance.
Griffin HLB systems hold an emulsion by balancing surfactant affinity. Classic holds it electrostatically: a multi-component anionic interfacial wall establishes mutual repulsion between droplets, so stability comes from the interface itself rather than from a ratio that has to keep holding. A charge-independent steric brush is added last, sits outermost, sets droplet size during processing and gives the system tolerance to cationic material added downstream.
NE
Nanoemulsion domain
Structural lipid dispersion. Carries the lipophilic load and receives the oil you add downstream.
NL
Nanoliposomal domain
Phospholipid bilayer organisation. This is where peptide and hydrophilic payload is absorbed and held.
NM
Nanomicellar reserve
Added cold, last. The compatibility buffer that sweeps free lipophile and keeps the architecture tolerant of what you add.
What that buys you
✕Legacy HLB: droplet size is whatever the mixer produced
→
✓~185 nm engineered by design, confirmed by DLS at QC
✕Legacy HLB: every new active means re-balancing the system
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✓Three domains absorb different payload classes independently
✕Legacy HLB: you need heat and high shear to build it
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✓Cold-processable downstream — gentle room-temperature mixing
✕Legacy HLB: readable off your INCI list by any competitor
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✓Performance lives in the architecture, not the ingredient deck
Bench characterisation on the current Classic architecture held the distribution to within instrument noise across a full 24-hour window that included a cold addition, a refrigerated hold and a rewarm to room temperature — no ripening, no coalescence, no detectable thermal-cycle damage in the primary mode.
Specification
What Classic is built to.
Every batch is characterised by Dynamic Light Scattering before release. Distribution is read across multiple angles rather than reported as a single number, because a single cumulant hides the tail that actually governs shelf life.
~185 nm
Engineered mean particle size
DLS
Multi-angle, intensity-weighted Z-average
5.9
Nominal pH; working floor 5.7
~85%
Typical use level in a finished serum
Parameter
NanoBase™ Classic
Notes
Formulation class
Fully modular tri-domain nano-delivery architecture
Serum class. Fluid, not a finished serum
Stabilisation
Engineered interfacial charge
Replaces HLB surfactant balancing
Downstream peptide load
Supports ~12%
Absorbed by the liposomal domain
Downstream oil load
Supports ~5%
Self-partitions into the nanoemulsion and micellar domains
Water phase
Built in
Never a need for added water in formulation
Added surfactant
None required
Micellar reserve is already built in
Processing downstream
Gentle mixing, 22–25 °C
No homogeniser, no sonication, no heat
Shear stability
Up to 12,000 rpm
Headroom for standard production equipment
Preservation
Non-ionic system
Phenoxyethanol level held under the Clean at Sephora cap; no charge-disrupting electrolytes
Characterisation is performed under controlled production conditions. Figures describe the engineered architecture itself; finished-product performance depends on the formula built on top of it.
Measured, not asserted
The instrument record.
NanoBase™ is engineered to a platform target of ~185 nm, and every batch is then characterised individually by Dynamic Light Scattering before release. Below is an actual analyser record from a Classic batch — the raw instrument output, not a redrawn chart.
161.9 nmZ-average for this batch (± 0.88)
0.120Polydispersity index (± 0.043)
UnimodalSingle population across three repeats
90.0°Scattering angle, aqueous diluent at 25 °C
Individual repeats: 162.7 / 161.1 / 161.9 nm. A polydispersity index below 0.20 indicates a narrow, well-controlled distribution; below 0.10 is generally treated as monodisperse. Batches are released on their own record rather than on the platform target. Full batch documentation is available under NDA for qualified development programmes.
How you use it
Four steps, no nano equipment.
The architecture is built in our lab. Your job downstream — or your contract manufacturer’s — is only to partition your actives into the domains the architecture has already made.
01
Start with the architecture
Classic goes in at roughly 85% of your finished serum. The water phase is built in, so there is never a need to add water.
02
Add your actives
Peptides, humectants, antioxidants, botanical extracts, up to about 12% peptide and 5% oil. Room temperature, gentle mixing.
03
Let it partition
The mixing does not emulsify anything. It distributes what you added into the nanoemulsion, liposomal and micellar domains already present.
04
Adjust and fill
Confirm pH sits at or above 5.7, then fill. No heating, no high shear, no specialist equipment anywhere in the process.
MANUFACTURE ANYWHERE
Any contract manufacturer can build your formula on Classic.
Because the architecture is fully modular and arrives already built, your CM never has to make it. There is no nano equipment to buy, no sonication step, no tech transfer and no specialist training — the entire downstream process is gentle room-temperature mixing with the equipment every contract manufacturer already owns. Bring us your existing CM, or we will introduce you to one. You own the formula and the SDS either way.
Compatibility
What it takes, and what it does not.
Works with
Designed for
- Peptides and peptide complexes
- Niacinamide and water-soluble actives
- Antioxidants and botanical extracts
- Humectants and polyol systems
- Light oils and lipophilic actives up to ~5%
- Fragrance oils at cosmetic use levels
Treatment serums
High active loads carried without the usual compatibility fight.
Booster concentrates
Short ingredient decks where the architecture does the work.
Lightweight gel-creams
Serum feel with more body, without moving to a cream architecture.
Hydrating elixirs
Humectant-forward systems with peptides held in the liposomal domain.
Peptide programmes
Charge-mapped so cationic peptides do not collapse the wall.
Clean-market lines
Non-ionic preservation compatible with clean retailer standards.
Build your serum on architecture.
Tell us what the product has to do. We will show you what it looks like engineered on Classic.
Questions? team@pensivebeauty.com