Regulatory & Safety Clarification
NanoBase™ is not classified as a cosmetic nanomaterial under current FDA, EU, or ISO cosmetic definitions. The platform does not utilize insoluble or persistent nanoparticles, nor does it employ intentionally manufactured nanomaterials under 120 nm requiring nano-labeling. Delivery performance is achieved through 125 nm - 195 nm organized nanostructured domains that enhance penetration, stability, and bioavailability, while remaining fully compliant with cosmetic regulatory frameworks and not classified as regulated nanomaterials.
NanoBase™
NanoBase™ is supported by a publicly archived technical document detailing nanoscale architecture, tri-domain delivery integration, and dynamic light scattering validation under controlled production conditions.
DOI: https://doi.org/10.5281/zenodo.18616576
The Modern Nanodelivery Platform for Performance-Driven Skincare
NanoBase™ is a modular nanodelivery platform engineered at ~165 nm by design, with a Polydispersity Index below 0.20, verified by Dynamic Light Scattering under controlled production conditions.
It replaces legacy HLB emulsification logic with a tri-domain nanoscale architecture engineered for ingredient performance at the skin interface, not just stability in the jar.
At its core, NanoBase™ functions as a structured lipid matrix integrating nanoemulsion, nanoliposomal, and nanomicellar domains into one coordinated system.
Why NanoBase™ Exists
Traditional HLB emulsions were designed to prevent separation.
They were not designed to optimize cosmetic deposition.
Modern actives have evolved. Delivery architecture must evolve with them.
NanoBase™ shifts formulation logic from surfactant balancing to nanoscale structural engineering, improving dispersion uniformity and performance predictability across diverse payloads.
The NanoBase™ Standard
Designed mean particle size: ~165 nm
Polydispersity Index: <0.20
Verification method: Dynamic Light Scattering, intensity-weighted Z-average
Architecture: Tri-domain nanoscale platform
Functional objective: Improved cosmetic ingredient distribution, bioavailability and retention at the skin interface
Regulatory positioning: Cosmetic delivery platform (not classified as nano-material)
Formulation & architecture intelligence by Pensive Beauty® Nanoscience Labs.
The Tri-Domain Architecture
NanoBase™ integrates three nanoscale domains into a unified matrix:
Nanoemulsion domain for structural lipid dispersion
Nanoliposomal domain for phospholipid-supported organization
Nanomicellar domain for stabilization and compatibility support
Instead of suspending actives statistically, NanoBase™ supports them structurally.
This reduces internal formulation conflict and increases dispersion consistency across oil-soluble, water-soluble, and hybrid systems.
What This Means for Brands
More consistent cosmetic performance
Better structural support for complex active systems
Higher predictability across different skin types
Modern architectural replacement for legacy HLB foundations
Scalable platform compatibility across serum, cream, and hybrid formats
NanoBase™ is not a trend-driven encapsulation gimmick.
It is an architectural upgrade.
Regulatory and Safety Positioning
NanoBase™ is a lipid-based cosmetic delivery platform built from skin-compatible components and engineered at nanoscale dimensions to improve ingredient distribution and retention.
It is positioned strictly for cosmetic applications and does not alter regulatory classification.
NanoBase™ is not positioned as an insoluble engineered nanomaterial. It is a biomimetic lipid matrix measured at nanoscale dimensions.
New Industry Standard
HLB solved shelf stability.
NanoBase™ solves bioavailability delivery architecture.
Ingredients matter. Architecture decides whether they perform.
Custom NanoDelivery Platforms
Some projects require a delivery system that doesn't exist yet. For brands who need more than our pre-engineered NanoBase™ platforms, we design fully bespoke NanoDelivery platform from the ground up & fully modular, so you can use any manufacture. Our nano delivery platforms create the most bioavailable form of delivery for beauty products available on the market, all in the fraction of time and cost, all while transforming how actives reach and perform at their target sites.
Every aspect: structure, particle size, compatibility, and stability can be tuned to meet the exact needs of your specific formulation or universal to your entire line.
What Makes a Custom System Different
Built for your actives: Engineered around the unique chemistry of your chosen ingredients for maximum bioavailability.
Tailored particle size: Adjustable nano ranges (typically 80–300 nm) for optimized penetration and release that conventional systems cannot achieve.
Expanded compatibility: Options for non-phospholipid or hybrid structures to handle pigments, peptides, and complex blends at nanoscale.
Revolutionary sublingual delivery: Now offering skin care from the inside out - delivering actives systemically through sublingual absorption for effects that topical applications can't achieve.
Flexible formats: Stable in serums, creams, masks, sublingual applications, or multi-phase systems while maintaining superior nano bioavailability.
Refined feel: Sensory profile designed to match your brand's target texture, from silky serums to luxurious creams.
Use Case Examples
Sublingual beauty systems - the first of their kind for systemic skin benefits without injections
Internal delivery of collagen peptides, antioxidants, and skin-supporting compounds with unprecedented absorption
Advanced treatment serums with high-active loads and maximum bioavailability
Specialty cosmetics needing pigment or optical effect dispersion at nanoscale
Research-driven projects exploring novel nano delivery chemistries
Formulas that combine both hydrophilic and lipophilic agents with enhanced bioavailability
Technical Parameters (Baseline Options)
Fully modular
Shear stability: up to 12,000 rpm
pH stability range: typically 5.0–6.0 (adjustable for custom needs and sublingual compatibility)
Compatible with: peptides, niacinamide, antioxidants, botanical extracts, pigment dispersions & more
Not recommended for: heavily wax-based systems or solvent-heavy alcohol formulations